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February 9, 2016Experimental and Therapeutic MedicineOpen Access

Time course of various cell origin circulating microparticles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention

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Key result

Primary PCI in STEMI patients led to an immediate increase in platelet microparticles and a significant decrease in leukocyte- and endothelial-derived microparticles, which subsequently increased over 48 hours.

Why the study?

What is the time course of changes in circulating microparticles of different cell origins in STEMI patients undergoing primary PCI?

Population

24 patients with ST-segment elevation myocardial infarction undergoing primary percutaneous transluminal…

Design

Cohort

Follow-up

48 hours

Authors

BZBoda ZhouJLJizhao LiSCShaomin Chen

Discussion

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Overview

Microparticle shifts after primary PCI in STEMI may reflect distinct cellular roles; leaves open biomarker utility pending prospective trials.

Study Design

Type

Observational (n=24)

Multicenter

No

Structured PICO

What is the time course of changes in circulating microparticles of different cell origins in STEMI patients undergoing primary PCI?

P
Population
24 patients (mean age 58 years, 37.5% female) with STEMI undergoing primary PCI within 12 hours of symptom onset, followed for 48 hours to assess circulating microparticle levels.
E
Exposure
Primary percutaneous transluminal coronary intervention (PCI)
O
Outcome
Time course of changes in circulating microparticles (endothelial, platelet, and leukocyte-derived) immediately prior to and after PCI, and at 4, 24 and 48 h post-PCIsurrogate

Main Result

Absolute Event Rate: 114% vs 250%

p-value: p=0.01

Circulating microparticles of different cellular origins exhibit distinct dynamic changes following primary PCI in STEMI patients, which may reflect their different pathophysiological roles.

Limitations

  • Small sample size
  • Single-center study
  • Lack of a non-PCI control group

Cite This Study

Zhou et al. (2016) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=24). Percutaneous transluminal coronary intervention (PCI) vs. Baseline (pre-PCI) was evaluated on Leukocyte-derived microparticle (LMP) levels immediately after PCI compared to baseline (p=0.01). Primary PCI in STEMI patients led to an immediate increase in platelet microparticles and a significant decrease in leukocyte- and endothelial-derived microparticles, which subsequently increased over 48 hours.

synapsesocial.com/papers/6a94c63f47dbabd73bdbce45https://doi.org/10.3892/etm.2016.3060
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microparticles during long-term follow-up after acute myocardial infarction2017 · 46 citations
  2. 2Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention2012 · 117 citations
  3. 3Circulating Platelet-Derived Microparticles Associated with Postdischarge Major Adverse Cardiac Events in ST-Elevation Acute Myocardial Infarction2020 · 7 citations
  4. 4Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome2015 · 21 citations
  5. 5Platelet-derived microparticle levels are significantly elevated in patients treated by elective stenting compared to subjects with diagnostic catheterization alone2010 · 20 citations