Key result
Elective bare metal stenting linked to ~71% higher platelet-derived microparticles versus diagnostic catheterization.
Why the study?
Does elective stenting with bare metal stent increase platelet-derived microparticle levels and platelet activation markers compared to diagnostic catheterization alone in patients with coronary artery disease on aspirin?
Population
Patients with coronary artery disease on aspirin antiplatelet pre-treatment
Comparison
Elective stenting with bare metal stent vs Diagnostic catheterization alone
Design
Cohort
Follow-up
15 minutes
Authors
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May signal heightened platelet activation post-stenting despite aspirin; leaves open whether microparticle levels predict thrombotic risk in CAD.
Observational
Does elective stenting with bare metal stent increase platelet-derived microparticle levels and platelet activation markers compared to diagnostic catheterization alone in patients with coronary artery disease on aspirin?
Absolute Event Rate: 557% vs 325%
p-value: p=< 0.05
Elective stenting with bare metal stents induces early and significant platelet activation and microparticle generation compared to diagnostic catheterization alone, despite aspirin pre-treatment.
Nagy et al. (2010) conducted an observational in Coronary artery disease. Elective stenting with bare metal stent vs. Diagnostic catheterization alone was evaluated on Level of platelet-derived microparticles (PMPs) at 15 minutes after completion (p=< 0.05). Elective stenting with bare metal stents significantly elevated platelet-derived microparticle levels compared to diagnostic catheterization alone (557 vs 325/microl; p<0.05).
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