Laboratory study demonstrates scalable allylic oxidation to enones using electricity and air, indicating an eco-friendly synthetic alternative.
A scalable and sustainable electrochemical protocol for allylic C-H aerobic oxidation has been developed, enabling the formation of enones without the use of stoichiometric toxic oxidants or metal catalysts and offering an environmentally benign alternative to traditional chemical oxidation techniques. The process has been successfully applied to selectively oxidize a series of natural products and drug molecules, underscoring its potential for widespread adoption in both academic and industrial contexts.
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Zhao et al. (2025) studied this question.
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