Why the study?
Does ephedrine improve uterine artery blood flow velocity in pregnant guinea pigs subjected to terbutaline infusion and acute hemorrhage?
Population
10 chronically instrumented pregnant guinea pigs near term
Comparison
Ephedrine 1.0 mg/kg administered intravenously vs Placebo
Design
Preclinical
Follow-up
acute (minutes)
Authors
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May inform vasopressor selection in experimental obstetric hemorrhage; hypothesis-generating and should not alter clinical practice.
Does ephedrine improve uterine artery blood flow velocity in pregnant guinea pigs subjected to terbutaline infusion and acute hemorrhage?
Ephedrine aids in the restoration of uterine artery blood flow velocity in pregnant guinea pigs rendered hypotensive by acute hemorrhage during terbutaline infusion.
Chestnut et al. (1987) studied this question.
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