Key result
Bolus ephedrine and mephentermine were equally efficacious in treating spinal-induced hypotension during cesarean section, despite a transiently higher systolic BP at 2 minutes with ephedrine (p<0.05).
Why the study?
Hypotension is a common complication of spinal anesthesia during cesarean delivery that may harm the mother and fetus, prompting a comparison of intravenous ephedrine and mephentermine for treating spinal-induced hypotension and their fetal effects.
Does ephedrine compared to mephentermine improve maintenance of arterial pressure and fetal outcomes in patients undergoing cesarean section under spinal anesthesia?
Population
60 patients undergoing lower segment cesarean section under spinal anesthesia
Comparison
Intravenous bolus ephedrine 6 mg vs mephentermine 6 mg
Design
Prospective, randomized, double-blind study
Authors
Loading...
Ephedrine offers better early systolic BP maintenance than mephentermine; confirms equivalent neonatal outcomes in cesarean spinal anesthesia.
RCT (n=60)
Double-blind
computer-generated random numbers
Does ephedrine compared to mephentermine improve maintenance of arterial pressure and fetal outcomes in patients undergoing cesarean section under spinal anesthesia?
Absolute Event Rate: 114.3% vs 106.1%
p-value: p=< 0.05
Ephedrine and mephentermine are equally efficacious in preventing spinal-induced hypotension during cesarean section and are associated with similar neonatal outcomes.
Linette et al. (2022) conducted an RCT in Spinal-induced hypotension during cesarean section (n=60). Ephedrine vs. Mephentermine 6 mg intravenous bolus was evaluated on Systolic blood pressure at the second minute (p=< 0.05). Bolus ephedrine and mephentermine were equally efficacious in treating spinal-induced hypotension during cesarean section, despite a transiently higher systolic BP at 2 minutes with ephedrine (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: