Key result
Two distinct RNA polymerase complexes, transcriptase and replicase, differing in host and viral protein content, were identified as separately responsible for transcription and replication of VSV genome RNA.
Authors
Loading...
Distinct VSV polymerase complexes separate transcription from replication; leaves open extension to other viruses and antiviral targeting.
Qanungo et al. (2004) studied Vesicular stomatitis virus (VSV) infection. Immunoaffinity purification of RNA polymerase complexes was evaluated on Identification and characterization of transcriptase and replicase complexes. Two distinct RNA polymerase complexes, transcriptase and replicase, differing in host and viral protein content, were identified as separately responsible for transcription and replication of VSV genome RNA.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: