March 1, 1969Proceedings of the National Academy of SciencesOpen Access

The Isolation of Two Enzyme-Ribonucleic Acid Complexes Involved in the Synthesis of Foot-and-Mouth Disease Virus Ribonucleic Acid

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Population

Baby hamster kidney cells infected with foot-and-mouth disease virus

Design

Preclinical

Authors

RARalph B. ArlinghausUniversity of Hawaiʻi at Mānoa JPJerome PolatnickPlum Island Animal Disease Center

Discussion

Member takes

Implication

Distinguishes polymerase roles in FMDV RNA synthesis; leaves open therapeutic targeting pending further validation.

Structured PICO

Population

Baby hamster kidney cells infected with foot-and-mouth disease virus

Intervention

Fractionation by zonal centrifugation in sucrose gradients

Outcome

Isolation and characterization of RNA polymerase complexes and their synthesized productssurrogate

The study identifies distinct RNA polymerase complexes responsible for synthesizing different forms of foot-and-mouth disease virus RNA in infected cells.

Cite This Study

Arlinghaus et al. (1969) studied this question.

synapsesocial.com/papers/6a225cce7d05348b2ab600da https://doi.org/10.1073/pnas.62.3.821

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The Isolation of Two Enzyme-Ribonucleic Acid Complexes Involved in the Synthesis of Foot-and-Mouth Disease Virus Ribonucleic Acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Isolation of Two Enzyme-Ribonucleic Acid Complexes Involved in the Synthesis of Foot-and-Mouth Disease Virus Ribonucleic Acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider