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Rapid Golgi transit of FMDV polymerase may guide trafficking-targeted antivirals; leaves open validation in other picornaviruses.
Electrophoretic analysis of the Golgi apparatus isolated by differential centrifugation from radiolabeled cells infected with foot-and-mouth disease virus showed about 10 protein bands. The virus-induced RNA polymerase was identified by immunoprecipitation and electron microscope staining procedures. Pulse-chase experiments indicated that the polymerase passed through the Golgi apparatus in less than 1 h.
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Polatnick et al. (1985) studied this question.
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