December 8, 1967Science

Detergent-Solubilized RNA Polymerase from Cells Infected with Foot-and-Mouth Disease Virus

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Population

Cells infected with Foot-and-Mouth Disease Virus

Design

Preclinical

Authors

Discussion

Enables cell-free FMDV RNA analysis; leaves open whether this advances antiviral strategies in livestock.

Population

Cells infected with Foot-and-Mouth Disease Virus

Intervention

Dissociation of RNA polymerase complex with deoxycholate in the presence of dextran sulfate

Outcome

Cell-free synthesis of virus-specific RNA and analysis of RNA componentssurrogate

Solubilization of the FMDV RNA polymerase complex with deoxycholate and dextran sulfate allows for direct analysis of cell-free viral RNA synthesis.

Arlinghaus et al. (1967) studied this question.

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