What does this research mean for the field?

The RNA-dependent RNA polymerase of Foot-and-Mouth Disease Virus is a 56,000 molecular weight virus-coded protein identical to the virus infection associated (VIA) antigen and protein P56, and is highly conserved across all seven viral serotypes. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1979Journal of General Virology

Purification and Identification of the RNA-dependent RNA Polymerase of Foot-and-Mouth Disease Virus

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Structured PICO

Population

BHK 21 cells infected with foot-and-mouth disease virus

Intervention

Purification of RNA-dependent RNA polymerase from the replication complex, including digestion with ribonuclease T1

Outcome

Identification and characterization of the major virus-coded protein in the RNA-dependent RNA polymerase

The RNA-dependent RNA polymerase of foot-and-mouth disease virus is identified as a highly conserved 56,000 MW protein that corresponds to the VIA antigen.

Discussion

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Implication

Highly conserved FMDV polymerase protein warrants further study as a pan-serotype target; leaves open therapeutic or diagnostic applications.

Cite This Study

Newman et al. (1979) studied this question.

synapsesocial.com/papers/6a1d36dd750575be8d2f4aa1 https://doi.org/10.1099/0022-1317-45-2-497

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Implication

Highly conserved FMDV polymerase protein warrants further study as a pan-serotype target; leaves open therapeutic or diagnostic applications.

Purification and Identification of the RNA-dependent RNA Polymerase of Foot-and-Mouth Disease Virus

Structured PICO

Discussion

Implication

Cite This Study

Purification and Identification of the RNA-dependent RNA Polymerase of Foot-and-Mouth Disease Virus

Structured PICO

Discussion

Implication

Cite This Study

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