Key result
Preexisting maternal cardiometabolic diseases were associated with a significantly increased risk of miscarriage (OR 1.25) compared to pregnancies without these conditions.
Why the study?
Increased miscarriage risk has been reported for specific conditions, but a broader investigation across categories of chronic illness was needed to uncover illness patterns.
Do preexisting chronic diseases, particularly cardiometabolic conditions, increase the risk of miscarriage in pregnant women?
Population
593,009 registered pregnancies in Norway between 2010 and 2016
Comparison
Risk of miscarriage according to various preexisting chronic diseases across six categories
Design
Registry-based study
Authors
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Cardiometabolic diseases may increase miscarriage risk; observational data leave open whether risk modification alters outcomes.
Observational (n=593,009)
Do preexisting chronic diseases, particularly cardiometabolic conditions, increase the risk of miscarriage in pregnant women?
Odds Ratio: 1.25 (95% CI 1.2–1.31)
p-value: p=<0.001
Preexisting cardiometabolic diseases, including atherosclerosis, hypertension, and type 2 diabetes, are significantly associated with an increased risk of miscarriage.
Magnus et al. (2021) conducted an observational in Pregnancy (n=593,009). Preexisting cardiometabolic diseases vs. Women without the specific chronic disease was evaluated on Risk of miscarriage (OR 1.25, 95% CI 1.20 to 1.31, p=<0.001). Preexisting maternal cardiometabolic diseases were associated with a significantly increased risk of miscarriage (OR 1.25) compared to pregnancies without these conditions.
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