Key result
Older donor age (RR 9.9), male donor (RR 3.2), high rejection scores (RR 2.01), and high cyclosporine at 3 months (RR 1.9) were significant predictors of cardiac allograft vasculopathy onset.
Why the study?
What are the immune and nonimmune predictors of cardiac allograft vasculopathy onset and severity in heart transplant patients?
Population
361 heart transplant patients
Design
Cohort
Follow-up
Up to 10 years
Authors
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May guide post-transplant risk stratification by donor and rejection factors; leaves open whether modifying them reduces cardiac allograft vasculopathy.
Cohort (n=361)
What are the immune and nonimmune predictors of cardiac allograft vasculopathy onset and severity in heart transplant patients?
Relative Risk: 9.9
p-value: p=<0.0001
High rejection scores predict the onset of cardiac allograft vasculopathy, suggesting an immune basis for its onset, while nonimmune factors like donor weight and pre-transplant coronary disease predict its severity and progression.
Caforio et al. (2004) conducted a cohort in Cardiac allograft vasculopathy in heart transplantation (n=361). Clinical and immunological risk factors (e.g., older donor age, high rejection scores) was evaluated on Cardiac allograft vasculopathy (CAV) onset (RR 9.9, p=<0.0001). Older donor age (RR 9.9), male donor (RR 3.2), high rejection scores (RR 2.01), and high cyclosporine at 3 months (RR 1.9) were significant predictors of cardiac allograft vasculopathy onset.
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