Key result
Heparin reduced fibrin and platelet development in arteries and veins, while clopidogrel reduced both in arteries and reduced platelet accumulation in venous thrombosis.
Why the study?
Does heparin or clopidogrel reduce fibrin and platelet accumulation in murine models of arterial and venous thrombosis?
Population
Murine model of large-vessel arterial or venous thrombosis
Design
Preclinical
Authors
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May inform preclinical thrombosis research; leaves open clinical translation of cross-modulatory antithrombotic effects.
Does heparin or clopidogrel reduce fibrin and platelet accumulation in murine models of arterial and venous thrombosis?
Inhibition of one thrombotic component (platelets or coagulation) shows cross-modulatory effects on the other in both arterial and venous thrombosis models.
Cooley et al. (2013) studied Large-vessel arterial or venous thrombosis. Heparin and clopidogrel was evaluated on Fibrin and platelet levels at the thrombus induction site. Heparin reduced fibrin and platelet development in arteries and veins, while clopidogrel reduced both in arteries and reduced platelet accumulation in venous thrombosis.
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