Key result
Among 24 children hospitalized with infective endocarditis, 54% had underlying congenital heart disease, 79% were culture-negative, and 29% died from the disease or its complications.
Why the study?
The characteristics of infective endocarditis have significantly changed in pediatric patients over recent decades, warranting assessment of its clinical profile, risk factors, cardiac involvement, and outcomes in Bangladesh.
Cross-Sectional (n=24)
No
In a pediatric cohort in Bangladesh, infective endocarditis is predominantly culture-negative and frequently associated with congenital heart disease, carrying a high mortality rate of 29%.
Background: The characteristics of infective endocarditis (IE) have significantly changed in pediatric age group during last few decades. The present study was conducted to study the clinical & lab profile, risk factors, site of cardiac involvement and outcome of infective endocarditis in the largest children hospital of Bangladesh. Methods: This prospective cross-sectional study was conducted in cardiology department with a diagnosis of IE from February 2014 to August 2016. Twenty- four children fulfilled the modified Duke diagnostic criteria. Results: Definite IE was found in 58% (14/24) patients, while the rest had possible IE. The most common presenting symptom was prolonged fever (> 2 weeks) & heart murmur. Most commonly encountered risk factors included congenital heart disease (54%), most commonly ventricular septal defect (21%). Two patients (8.3%) had history of rheumatic heart disease. Other important risk factors include post cardiac surgery (16.7%), prolonged ICU stay of neonates (20.8%). Nineteen patients (79%) were classified as having culture-negative endocarditis and five (21%) as culture positive. The most frequently isolated organisms were streptococci and followed by staphylococci and candida. Fifteen (62.5%) patients had right-sided cardiac involvement. Seven (29%) patients died of endocarditis or its complications. Conclusion: Clinicians should have a high index of suspicion of endocarditis in persistently febrile patients with congenital heart disease and send blood cultures or refer appropriately before prescribing antibiotics. Cardiovasc. j. 2019; 12(1): 33-39
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Rima et al. (2019) conducted a cross-sectional in Infective endocarditis (n=24). Infective endocarditis was evaluated on Death from endocarditis or its complications. Among 24 children hospitalized with infective endocarditis, 54% had underlying congenital heart disease, 79% were culture-negative, and 29% died from the disease or its complications.
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