Key result
The G allele of the MMP-2 rs11643630 polymorphism was associated with a significantly lower risk of type A aortic dissection (OR 0.705).
Why the study?
Are MMP-2 gene polymorphisms associated with type A aortic dissection risk and aortic diameters?
Case-Control (n=611)
No
Are MMP-2 gene polymorphisms associated with type A aortic dissection risk and aortic diameters?
Odds Ratio: 0.705 (95% CI 0.545–0.912)
Absolute Event Rate: 36.1% vs 44.4%
p-value: p=0.008
The MMP-2 gene polymorphism rs11643630 is associated with a reduced risk of type A aortic dissection and smaller aortic diameters.
Supports MMP-2 variant as potential biomarker; leaves open prospective validation before any clinical use.
Matrix metalloproteinases-2 (MMP-2) plays an important role in the pathogenesis of type A aortic dissection (AD). The aim of this study was to evaluate the association of 3 single nucleotide polymorphisms (SNPs) in the MMP-2 gene with type A AD risk and aortic diameters in patients. We performed a case-control study with 172 unrelated type A AD patients and 439 controls. Three SNPs rs11644561, rs11643630, and rs243865 were genotyped through the MassARRAY platform. Allelic associations of SNPs and SNP haplotypes with type A AD and aortic diameters in patients were evaluated. The frequency of the G allele of the rs11643630 polymorphism was significantly lower in type A AD patients than in control subjects (odds ratio 0.705, 95% confidence interval 0.545-0.912, P = 0.008). The association remained significant after adjusting for clinical covariates (P = 0.008). Carriers of the GG genotype of the rs11643630 polymorphism had significantly smaller aortic diameters than those with GT genotype or TT genotype (P = 0.02). Further haplotype analysis identified 1 protective haplotype (GC; P = 0.008) for development of type A AD. Again, a significant correlation was observed between haplotype GC and AD size (P = 0.020). Our results suggest that MMP-2 gene polymorphisms contribute to type A AD susceptibility. In addition, MMP-2 gene SNPs are associated with AD size, which could be used as a target for the development of new drug therapy.
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Liu et al. (2016) conducted a case-control in Type A aortic dissection (n=611). MMP-2 gene rs11643630 G allele vs. Non-carriers / Control subjects was evaluated on Association of the rs11643630 G allele with type A aortic dissection (OR 0.705, 95% CI 0.545-0.912, p=0.008). The G allele of the MMP-2 rs11643630 polymorphism was associated with a significantly lower risk of type A aortic dissection (OR 0.705).
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