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August 27, 2007Journal of Addictive Diseases

Physician Awareness of the Cardiac Effects of Methadone

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Key result

Only 41% (95% CI 37-45) of medical directors at U.S. opioid treatment programs were aware of methadone's QT-prolonging properties, and just 24% were aware of its association with torsade de pointes.

Population

692 physicians licensed as medical directors for accredited U.S. opioid treatment programs in 2006

Design

Cross-sectional

Authors

MKMori J. KrantzAmerican College of CardiologySRShane RowanMetroHealth Medical CenterJSJohn SchmittnerBaylor Scott & White Medical Center - Temple

Discussion

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Implication

Low awareness of methadone's QT risks among OTP directors may warrant targeted education; leaves open effects on prescribing or arrhythmia outcomes.

Study Design

Type

Cross-Sectional (n=692)

Multicenter

Yes

Structured PICO

P
Population
692 physicians licensed as medical directors for accredited U.S. opioid treatment programs surveyed in 2006 regarding awareness of methadone's cardiac effects.
E
Exposure
National mail survey assessing awareness of methadone's QT-prolonging properties
O
Outcome
Knowledge of methadone's QT-prolonging effects

A national survey revealed that a majority of opioid treatment program physicians are unaware of methadone's QT-prolonging properties and its association with torsade de pointes.

Cite This Study

Krantz et al. (2007) conducted a cross-sectional in Opioid dependence treatment (n=692). Survey of physician awareness was evaluated on Knowledge of methadone's QT-prolonging effects (95% CI 37-45). Only 41% (95% CI 37-45) of medical directors at U.S. opioid treatment programs were aware of methadone's QT-prolonging properties, and just 24% were aware of its association with torsade de pointes.

synapsesocial.com/papers/6a950733a15fb1352cb2d356https://doi.org/10.1300/j069v26n04_10
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Buprenorphine on Cardiac Repolarization in a Patient with Methadone‐Related Torsade de Pointes2005 · 63 citations
  2. 2Drug-Induced Long QT Syndrome in Injection Drug Users Receiving Methadone2006 · 232 citations
  3. 3β-Blocker Underuse in Secondary Prevention of Myocardial Infarction2004 · 58 citations
  4. 4A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction1992 · 1,541 citations
  5. 5Relationships Between Counseling Rapport and Drug Abuse Treatment Outcomes2001 · 149 citations