Key result
The prevalence of acquired long QT syndrome at emergency department admission was 7.82%, with antibiotic and antipsychotic use identified as major risk factors for severely prolonged QTc.
Why the study?
The real-world prevalence of acquired long QT syndrome in the emergency department remained to be determined.
What is the prevalence and what are the risk factors for acquired long QT syndrome in the emergency department?
Observational (n=4,900)
No
What is the prevalence and what are the risk factors for acquired long QT syndrome in the emergency department?
Acquired long QT syndrome is prevalent in the emergency department, particularly among females taking antibiotics and antipsychotics, highlighting the need for early detection.
BACKGROUND: Long QT syndrome (LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS (aLQTS) in the emergency department (ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED admissions. METHODS: of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT (QTc) interval greater than 500 ms (value that is considered severely increased). RESULTS: 1.925). CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.
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Fernandes et al. (2023) conducted an observational in Acquired long QT syndrome (n=4,900). QT prolonging drugs and clinical risk factors vs. Unexposed patients was evaluated on Prevalence of acquired long QT syndrome (aLQTS) at admission to the ED. The prevalence of acquired long QT syndrome at emergency department admission was 7.82%, with antibiotic and antipsychotic use identified as major risk factors for severely prolonged QTc.
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