Key result
Significant mitral regurgitation prior to TAVI was associated with higher unadjusted short-term mortality (RR 1.46; 95% CI 1.30-1.65), but most studies found no association after adjustment.
Why the study?
Mitral regurgitation is common in severe aortic stenosis, but its independent impact on mortality after TAVI has not been established.
Does the presence of significant mitral regurgitation prior to TAVI increase mortality in patients with severe aortic stenosis?
Meta-Analysis (n=32,257)
Does the presence of significant mitral regurgitation prior to TAVI increase mortality in patients with severe aortic stenosis?
Relative Risk: 1.46 (95% CI 1.3–1.65)
Significant mitral regurgitation prior to TAVI is associated with higher unadjusted mortality due to baseline comorbidities, but lacks robust evidence for an independent impact on mortality after adjustment.
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Moderate-severe MR was associated with higher post-TAVI mortality; leaves open whether targeted intervention improves outcomes.
Sethi et al. (2020) conducted a meta-analysis in Severe aortic stenosis (n=32,257). Significant mitral regurgitation vs. Without significant mitral regurgitation was evaluated on Unadjusted short-term mortality (RR 1.46, 95% CI 1.30-1.65). Significant mitral regurgitation prior to TAVI was associated with higher unadjusted short-term mortality (RR 1.46; 95% CI 1.30-1.65), but most studies found no association after adjustment.
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