Why the study?
Does transplantation of fibroblasts primed with survival factors improve cell engraftment and induce myocardial fibrosis in animal models?
Does transplantation of fibroblasts primed with survival factors improve cell engraftment and induce myocardial fibrosis in animal models?
Priming fibroblasts with survival factors prior to transplantation significantly improves cell engraftment and induces targeted myocardial fibrosis and conduction delay, offering a potential novel strategy for treating arrhythmias.
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Priming boosts engraftment yet increases fibrosis and delay in animals; leaves open translation to human arrhythmia therapy.
Lee et al. (2011) studied this question.
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