An ultrasonic methodology can estimate the kinematic viscosity coefficient of blood in simulations and phantom experiments, potentially offering a noninvasive tool for predicting plaque rupture.
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Ultrasonic blood viscosity estimation remains preclinical; leaves open translation to noninvasive plaque rupture prediction.
Although plaque rupture in arteriosclerosis is affected by not only its strength but also by hemodynamic factors, such as blood pressure and shear stress, in particular, the viscous coefficient which directly controls the magnitude of shear stress might be a risk factor in plaque rupture. Therefore, if the viscous coefficient can be assessed noninvasively, it can be a useful index for prediction of a plaque rupture and assessment of various diseases. In this work, an ultrasonic methodology to estimate the viscous coefficient was investigated by numerical simulation and flow-phantom experiment as the fundamental investigation for noninvasively assessing the viscous characteristics of blood. These results show that the proposed method is useful for estimating the kinematic viscosity coefficient in the viscous evaluation of blood.
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Nitta et al. (2005) studied this question.
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