Key result
Lower carotid viscous parameters are linked to absent plaque, suggesting utility in detecting early atherosclerosis.
Why the study?
Vascular wall viscosity may be important for diagnosing vascular disease, but has received less attention than elasticity due to clinical measurement difficulties.
Can viscous parameters estimated from carotid ultrasound and brachial pressure waveforms detect early atherosclerosis (low plaque burden)?
Observational
Can viscous parameters estimated from carotid ultrasound and brachial pressure waveforms detect early atherosclerosis (low plaque burden)?
Viscous parameters derived from carotid ultrasound and brachial pressure waveforms may serve as a novel mechanical index for detecting early atherosclerosis.
Answers are grounded in this paper and cite their sources.
May support viscous parameters for early atherosclerosis detection; hypothesis-generating and requires prospective validation before clinical adoption.
Viscoelasticity may be an important physical index for diagnosing vascular diseases, but wall viscosity has received less attention than elasticity due to difficulties in measurement in clinical scenarios. In this study, viscoelastic parameters were estimated from the pressure diameter relationship using carotid artery ultrasound images and brachial artery pressure waveforms of the patients. Carotid artery diameter waveforms were obtained by analyzing wall motion in ultrasound cine images, and carotid pressure waveforms were estimated from brachial waveforms using a transfer function. The estimated viscoelastic parameters quantitatively agreed with the published data, and three viscous parameters (viscous index, energy dissipation ratio, and phase lag between pressure and diameter waveforms) showed good positive correlations with each other. No significant difference in wall elasticity was found between the no plaque (NP) and low plaque (LP) groups, whereas viscous parameters were lower in the NP group than the LP group. This result suggests that the viscous parameters may be a new mechanical index for detecting early atherosclerosis.
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Shin et al. (2022) conducted an observational in Atherosclerosis. Viscoelastic parameter estimation vs. No plaque vs low plaque groups was evaluated on Viscous parameters and wall elasticity. Viscous parameters estimated from carotid ultrasound and brachial pressure were lower in the no plaque group compared to the low plaque group, suggesting utility in detecting early atherosclerosis.
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