What question did this study set out to answer?

To compare 3-year locoregional cancer recurrence rates and survival outcomes between laparoscopic and open surgical resection in patients with rectal cancer.

July 8, 2015New England Journal of Medicine

A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer

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Authors

DKDavid KearneyRoyal College of Surgeons in Ireland JCJohn Calvin CoffeyRoyal College of Surgeons in Ireland

Discussion

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Implication

Randomized trial finds equivalent 3-year recurrence and survival rates between laparoscopic and open surgery in rectal cancer, indicating laparoscopic resection is a viable alternative.

Key Points

To compare 3-year locoregional cancer recurrence rates and survival outcomes between laparoscopic and open surgical resection in patients with rectal cancer.
Conducted an international randomized trial across 30 hospitals (N=1044; NCT00297791) randomly assigning patients in a 2:1 ratio to laparoscopic surgery (n=699) or open surgery (n=345).
Included patients with solitary adenocarcinoma of the rectum within 15 cm of the anal verge, without invasion into adjacent tissues and without distant metastases.
Evaluated locoregional recurrence 3 years after surgery as the primary end point, alongside secondary end points of disease-free survival and overall survival.
At 3 years, the locoregional recurrence rate was 5.0% in both the laparoscopic-surgery and open-surgery groups (difference, 0 percentage points; 90% CI, -2.6 to 2.6).
Three-year disease-free survival was 74.8% in the laparoscopic group versus 70.8% in the open-surgery group (difference, 4.0 percentage points; 95% CI, -1.9 to 9.9).
Three-year overall survival was 86.7% for laparoscopic surgery versus 83.6% for open surgery (difference, 3.1 percentage points; 95% CI, -1.6 to 7.8).

Cite This Study

Kearney et al. (2015) studied this question.

synapsesocial.com/papers/6a952e970cf8d0f2c97cf5af https://doi.org/10.1056/nejmc1505367

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July 8, 2015New England Journal of Medicine

A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer

View Full Paper

Ask AI

Bookmark

Authors

DKDavid KearneyRoyal College of Surgeons in Ireland JCJohn Calvin CoffeyRoyal College of Surgeons in Ireland

Discussion

Member takes

Implication

Randomized trial finds equivalent 3-year recurrence and survival rates between laparoscopic and open surgery in rectal cancer, indicating laparoscopic resection is a viable alternative.

Key Points

To compare 3-year locoregional cancer recurrence rates and survival outcomes between laparoscopic and open surgical resection in patients with rectal cancer.
Conducted an international randomized trial across 30 hospitals (N=1044; NCT00297791) randomly assigning patients in a 2:1 ratio to laparoscopic surgery (n=699) or open surgery (n=345).
Included patients with solitary adenocarcinoma of the rectum within 15 cm of the anal verge, without invasion into adjacent tissues and without distant metastases.
Evaluated locoregional recurrence 3 years after surgery as the primary end point, alongside secondary end points of disease-free survival and overall survival.
At 3 years, the locoregional recurrence rate was 5.0% in both the laparoscopic-surgery and open-surgery groups (difference, 0 percentage points; 90% CI, -2.6 to 2.6).
Three-year disease-free survival was 74.8% in the laparoscopic group versus 70.8% in the open-surgery group (difference, 4.0 percentage points; 95% CI, -1.9 to 9.9).
Three-year overall survival was 86.7% for laparoscopic surgery versus 83.6% for open surgery (difference, 3.1 percentage points; 95% CI, -1.6 to 7.8).

Cite This Study

Kearney et al. (2015) studied this question.

synapsesocial.com/papers/6a952e970cf8d0f2c97cf5af https://doi.org/10.1056/nejmc1505367

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