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July 11, 2014Molecular and Clinical OncologyOpen Access

Laparoscopic surgery for rectal cancer resulted in similar 5-year overall survival (HR 1.10) compared to open surgery, while significantly reducing hospital duration by 2.66 days.

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Why the study?

Does laparoscopic surgery improve clinical efficacy and recovery compared to open surgery in patients with rectal cancer?

Population

2,114 patients with rectal cancer from 14 randomized controlled trials

Comparison

Laparoscopic surgery vs Conventional open surgery (laparotomy)

Design

Meta-analysis

Follow-up

Up to 5 years

Key result

Laparoscopic surgery for rectal cancer resulted in similar 5-year overall survival (HR 1.10) compared to open surgery, while significantly reducing hospital duration by 2.66 days.

Authors

JZJUN-KANG ZHAONCNanzheng ChenJZJianbao Zheng

Discussion

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Member takes

Overview

Supports laparoscopic rectal resection for faster recovery; confirms equivalent oncologic outcomes and survival versus open surgery.

Study Design

Type

Meta-Analysis (n=2,114)

Structured PICO

Does laparoscopic surgery improve clinical efficacy and recovery compared to open surgery in patients with rectal cancer?

P
Population
2,114 patients with rectal cancer included in a meta-analysis of 14 randomized controlled trials comparing laparoscopic versus open surgery.
I
Intervention
Laparoscopic surgery
C
Comparator
Conventional open surgery (laparotomy)
O
Outcome
Clinical efficacy including surgical data (blood loss, surgical time), postoperative recovery (hospital duration, time to flatus), complications, and prognosis (3-year and 5-year overall and disease-free survival)

Main Result

Hazard Ratio: 1.1 (95% CI 0.77–1.58)

p-value: p=0.60

Laparoscopic surgery for rectal cancer offers faster postoperative recovery with comparable oncological outcomes and survival to traditional open surgery.

Limitations

  • The included RCTs did not clearly state total mesorectal excision (TME) as a surgical approach.
  • The study did not perform subgroup analysis.
  • Included RCTs did not clearly state total mesorectal excision (TME) as a surgical approach
  • No subgroup analysis performed

Cite This Study

ZHAO et al. (2014) conducted a meta-analysis in Rectal cancer (n=2,114). Laparoscopic surgery vs. Open surgery was evaluated on 5-year overall survival (HR 1.10, 95% CI 0.77 to 1.58, p=0.60). Laparoscopic surgery for rectal cancer resulted in similar 5-year overall survival (HR 1.10) compared to open surgery, while significantly reducing hospital duration by 2.66 days.

synapsesocial.com/papers/6aa01078857570eec471e4ffhttps://doi.org/10.3892/mco.2014.345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of open and laparoscopic surgical techniques in colorectal cancer surgery: Early and late results2026
  2. 2Letter 4: Randomized clinical trial comparing laparoscopic and open surgery in patients with rectal cancer (<i>Br J Surg</i> 2009; 96: 982–989)2009 · 1 citations
  3. 3Laparoscopic-assisted vs open surgery for low rectal cancer: 5-year outcomes of the LASRE randomized clinical trial.2024 · 1 citations
  4. 4Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study2011 · 49 citations
  5. 5Robotic Versus Laparoscopic Versus Open Surgery for Rectal Cancer2025 · 11 citations