March 24, 2006Nephron Physiology

Mechanism of Vasopressin-Induced Contraction of Renal Medullary Interstitial Cells

View Full Paper

Ask AI

Bookmark

Population

Cultured rat renomedullary interstitial cells (RMIC)

Design

Preclinical

Authors

AHAlisa K. HughesUniversity of Utah DKDonald E. KohanBrigham and Women's Hospital

Discussion

Member takes

Implication

May inform renal interstitial cell models; leaves open translation to human physiology or disease.

Structured PICO

Population

Cultured rat renomedullary interstitial cells (RMIC)

Intervention

Vasopressin (AVP) and various pharmacological agents (V1/V2 receptor blockers, nifedipine, nickel, H7, NMMA, indomethacin, PGE2)

Outcome

RMIC surface area (contraction)surrogate

Vasopressin potently contracts cultured rat renomedullary interstitial cells via V1 receptor stimulation of PKC and intracellular calcium accumulation, a process downregulated by AVP-stimulated prostaglandin production.

Cite This Study

Hughes et al. (2006) studied this question.

synapsesocial.com/papers/6a953abedc88abd75325e55e https://doi.org/10.1159/000092245

View Full Paper

Ask AI

Bookmark

Mechanism of Vasopressin-Induced Contraction of Renal Medullary Interstitial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of Vasopressin-Induced Contraction of Renal Medullary Interstitial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider