Regioselective β‐Trifluoromethylation of β‐Silylporphyrins by Using a Trifluoromethyl Copper Complex

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We developed a method for the regioselective β‐trifluoromethylation of β‐silylated Zn(II) porphyrins by using a phenanthroline and triphenylphosphine‐ligated trifluoromethyl–copper complex [(phen)(Ph3P)CuCF3]. The regioselective porphyrin trifluoromethylation, which occurs under mild conditions, exhibits excellent substrate generality and functional group compatibility.