Why the study?
Does mechanical stretch induce delayed depolarization in cultured neonatal rat cortical neurons?
Population
Neonatal rat cortical neurons cultured on a flexible silastic membrane
Comparison
Rapid and reversible stretch by a 50-ms pulse of… vs Baseline values / unstretched state
Design
Preclinical
Follow-up
Up to 24 hours
Authors
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Offers cellular model for stretch-induced neuronal changes in TBI; leaves open in vivo and clinical translation.
Does mechanical stretch induce delayed depolarization in cultured neonatal rat cortical neurons?
Mechanical stretch of cultured cortical neurons induces a delayed depolarization dependent on neuronal firing, calcium entry, and NMDA receptor activation, providing an in vitro model for traumatic brain injury mechanisms.
Tavalin et al. (1995) studied this question.
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