Key result
Mechanical stretch triggers delayed depolarization in cortical neurons via Na pump inhibition following energy depletion.
Population
Cortical neurons in an in vitro model of traumatic brain injury
Comparison
Mechanical stretch-injury or exposure to 10… vs Control (unstretched or unexposed) neurons
Design
Preclinical
Authors
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May inform metabolic interventions to stabilize neuronal membrane potential after injury; leaves open translation to in vivo neurotrauma models.
Na pump inhibition secondary to altered cellular energetics underlies delayed depolarization in cortical neurons after mechanical injury or glutamate exposure.
Tavalin et al. (1997) studied Traumatic brain injury (in vitro model). Mechanical injury (stretch) or exogenous glutamate vs. Control neurons was evaluated on Resting membrane potential (RMP) depolarization (SIDD) and Na pump inhibition. Stretch-induced delayed depolarization (SIDD) in cortical neurons is mediated by Na pump inhibition secondary to reduced energy levels, which can be mimicked by exogenous glutamate exposure.
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