The study describes improved methods for producing rabbit-derived diagnostic sera for non-polio enteroviruses to overcome the limited availability of traditional horse reference sera.
May expand access to enteroviral neutralization diagnostics; leaves open standardization and clinical validation before routine adoption.
The human non-polio enteroviruses (NPEV) are ubiquitous viruses found worldwide. NPEV are etiological agents of various diseases. Traditional method of identification NPEV is the detection of serotype with the use of neutralizing serotype-specific sera. Limiting amount ofproduced horse enteroviruses reference serum is not available for practical diagnostic laboratories. In the paper there are presented the results of the improvement of methods for delivery of diagnostic enteroviral rabbit sera for the reaction of neutralization in amounts sufficient to national health care.
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В.Г. Козлов (2014) studied this question.
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