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September 8, 2014CirculationOpen Access

Long-Term Results (≤18 Years) of the Edge-to-Edge Mitral Valve Repair Without Annuloplasty in Degenerative Mitral Regurgitation

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Why the study?

Does edge-to-edge mitral valve repair without annuloplasty provide satisfactory long-term outcomes in patients with degenerative mitral regurgitation?

Population

61 patients with degenerative mitral regurgitation treated between 1993 and 2002. Annuloplasty was omitted…

Design

Cohort

Follow-up

mean 9.2±4.21 years; median 9.7 years; longest 18.1 years

Key result

Edge-to-edge mitral repair without annuloplasty for degenerative MR showed unsatisfactory long-term results; residual MR >1+ at discharge predicted recurrence of MR ≥3+ (HR 3.8; 95% CI 1.7-8.2).

Authors

MBMichele De BonisELElisabetta LapennaFMFrancesco Maisano

Discussion

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Member takes

Overview

Does not support routine edge-to-edge repair without annuloplasty in degenerative MR; leaves open whether annuloplasty addition improves durability.

Study Design

Type

Cohort (n=61)

Structured PICO

Does edge-to-edge mitral valve repair without annuloplasty provide satisfactory long-term outcomes in patients with degenerative mitral regurgitation?

P
Population
61 patients with degenerative mitral regurgitation treated with isolated edge-to-edge suture without annuloplasty, followed for a mean of 9.2 years.
E
Exposure
Isolated edge-to-edge mitral valve repair without annuloplasty (double-orifice repair in 53 patients, commissural edge-to-edge in 8 patients).
O
Outcome
Long-term survival, freedom from reoperation, and freedom from recurrence of MR ≥3+hard clinical

Main Result

Hazard Ratio: 3.8 (95% CI 1.7–8.2)

p-value: p=0.001

Surgical edge-to-edge mitral valve repair without annuloplasty for degenerative MR yields unsatisfactory long-term results, with high rates of recurrent severe regurgitation.

Cite This Study

Bonis et al. (2014) conducted a cohort in Degenerative mitral regurgitation (n=61). Edge-to-edge mitral repair without annuloplasty was evaluated on Recurrence of MR ≥3+ (HR 3.8, 95% CI 1.7-8.2, p=0.001). Edge-to-edge mitral repair without annuloplasty for degenerative MR showed unsatisfactory long-term results; residual MR >1+ at discharge predicted recurrence of MR ≥3+ (HR 3.8; 95% CI 1.7-8.2).

synapsesocial.com/papers/6a95468bc05e7b5813b2e3c2https://doi.org/10.1161/circulationaha.113.007885
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