Key result
Heart transplantation for valvular disease (3-5% of indications) is associated with slight primary excess mortality but identical long-term results compared to other etiologies.
Why the study?
Does heart transplantation for end-stage valvular disease have comparable outcomes to transplantation for other etiologies?
Does heart transplantation for end-stage valvular disease have comparable outcomes to transplantation for other etiologies?
Heart transplantation for end-stage valvular disease is associated with higher early mortality due to prior reoperations but offers long-term survival comparable to other transplant indications.
Early mortality warrants caution in valvular transplant selection; extends observational data but leaves open prospective validation.
PURPOSE OF REVIEW: The aim of this study is to appraise the indications of a small group of heart transplanted patients with valvular disease, to analyse both their particular issues and results compared with the etiologies of other transplanted patients. RECENT FINDINGS: Analysis of recent data shows that valvular patients represent between 3 and 5% of transplantation indications. This proportion of valvular patients had a tendency to decrease in many countries. These patients on the whole have undergone multiple reoperations. Pulmonary resistance analysis has to be especially rigorous for this group. A primary excess mortality is directly related to multiple reoperations. Mean and long-term results are then strictly comparable with other etiologies. There are a few very specific indications for recurrent endocarditis in this group. SUMMARY: Valvular patients represent a subgroup of transplanted patients with a slight primary excess mortality but with identical long-term results.
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Alain Pavie (2006) conducted a review in End-stage valvular disease. Heart transplantation vs. Other etiologies of transplanted patients was evaluated. Heart transplantation for valvular disease (3-5% of indications) is associated with slight primary excess mortality but identical long-term results compared to other etiologies.
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