Key result
Qishen Yiqi dropping pills significantly reduced the myocardial infarction area to 22.15% compared to 38.56% in the model group of rats with chronic heart failure.
Why the study?
Do Qishen Yiqi dropping pills reduce myocardial injury and apoptosis in a rat model of chronic heart failure?
Population
60 specific-pathogen-free Sprague-Dawley male rats weighing 250-360 g with chronic heart failure induced by…
Comparison
Qishen Yiqi dropping pills intragastrically… vs Same amount of normal saline administered to the…
Design
Preclinical, random table method
Follow-up
4 weeks
Authors
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May support cardioprotection in chronic heart failure models; leaves open clinical translation pending human trials.
Do Qishen Yiqi dropping pills reduce myocardial injury and apoptosis in a rat model of chronic heart failure?
Absolute Event Rate: 22.15% vs 38.56%
p-value: p=<0.05
Qishen Yiqi dropping pills attenuate myocardial injury, reduce infarct size, and decrease apoptosis in a rat model of chronic heart failure, likely by inhibiting the TGF-β1/Smads and caspase-3 signaling pathways.
Lu et al. (2018) studied Chronic heart failure (n=60). Qishen Yiqi dropping pills vs. Normal saline was evaluated on Myocardial infarction area (p=<0.05). Qishen Yiqi dropping pills significantly reduced the myocardial infarction area to 22.15% compared to 38.56% in the model group of rats with chronic heart failure.
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