Key result
Pre-hypertension was associated with significantly elevated levels of endothelin-1 (13.43 pg/mL vs 3.44 pg/mL, p<0.001), lipid bound sialic acid, and malondialdehyde compared to normotensive controls.
Why the study?
The mechanism underlying the progression of pre-hypertension to hypertension remains unclear.
Case-Control (n=60)
No
Absolute Event Rate: 13.43% vs 3.44%
p-value: p=<0.001
Elevated endothelin-1, lipid bound sialic acid, and malondialdehyde are associated with pre-hypertension and may serve as early markers for endothelial dysfunction and cardiovascular risk.
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Gopal et al. (2019) conducted a case-control in Pre-hypertension (n=60). Pre-hypertension vs. Normotension was evaluated on Endothelin-1 (ET-1) levels (pg/mL) (p=<0.001). Pre-hypertension was associated with significantly elevated levels of endothelin-1 (13.43 pg/mL vs 3.44 pg/mL, p<0.001), lipid bound sialic acid, and malondialdehyde compared to normotensive controls.
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