Key result
Genetic polymorphisms in the endothelin-1 and TNF-alpha genes were not significantly associated with plasma levels of big endothelin, endothelin-1, or TNF-alpha in patients with chronic heart failure.
Cross-Sectional (n=266)
No
p-value: p=0.819
Genetic polymorphisms in endothelin and TNF-alpha genes do not significantly affect their plasma levels in heart failure patients, suggesting hemodynamic status plays a more crucial role in humoral activation.
No association with polymorphisms observed; leaves open hemodynamic primacy over genetics in HF humoral activation.
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Špinarová et al. (2007) conducted a cross-sectional in Chronic heart failure (n=266). Genetic polymorphisms of endothelin-1 and TNF-alpha vs. Alternative genotypes was evaluated on Association between endothelin-1 G8002A polymorphism and plasma levels of big endothelin (p=0.819). Genetic polymorphisms in the endothelin-1 and TNF-alpha genes were not significantly associated with plasma levels of big endothelin, endothelin-1, or TNF-alpha in patients with chronic heart failure.
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