Key result
Multicenter study design details an investigation into genetic determinants of prognosis in ACS survivors.
Why the study?
Significant interindividual differences in outcomes after acute coronary syndromes exist despite similar risk profiles, with genetic factors playing a key role.
Do specific genetic polymorphisms predict the occurrence and prognosis of acute coronary syndromes in the Czech population?
Do specific genetic polymorphisms predict the occurrence and prognosis of acute coronary syndromes in the Czech population?
This paper outlines the design of a large multicenter study in the Czech Republic to investigate the genetic determinants of acute coronary syndromes and their subsequent prognosis.
Genetic factors may explain post-ACS outcome variability; leaves open whether genotyping improves risk stratification or outcomes.
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Piťha et al. (2007) studied Acute coronary syndromes (n=5,100). Genetic polymorphisms (connexin 37, stromelysin-1, PAI-1, lymphotoxin-alpha) vs. General population controls / alternative genotypes was evaluated on Identification of alleles and genotypes responsible for acute coronary events and recurrent events. This paper describes the design and rationale for a multicenter study investigating the genetic determinants of prognosis in survivors of acute coronary syndromes in the Czech Republic.
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