Key result
The interventional diagnostic procedure enables differentiation between INOCA clinical endotypes, allowing for stratified medical therapy to reduce symptom burden and improve quality of life.
Why the study?
INOCA remains a diagnostic and therapeutic challenge because anatomical investigation fails to account for disorders of vasomotion, and IDP use in daily practice remains limited despite guideline support.
Does the interventional diagnostic procedure (IDP) with linked stratified medical therapy improve symptom burden and quality of life in patients with INOCA?
Does the interventional diagnostic procedure (IDP) with linked stratified medical therapy improve symptom burden and quality of life in patients with INOCA?
Widespread adoption of the interventional diagnostic procedure (IDP) for INOCA is encouraged to enable personalized, stratified medical therapy that improves patient symptoms and quality of life.
May improve INOCA symptoms via IDP-stratified therapy; hypothesis-generating and requires randomized confirmation before adoption.
Ischaemia with non-obstructed coronary artery disease (INOCA) remains a diagnostic and therapeutic challenge. An anatomical investigationbased approach to ischaemic heart disease fails to account for disorders of vasomotion. The main INOCA endotypes are microvascular angina, vasospastic angina, mixed (both) or non-cardiac symptoms. The interventional diagnostic procedure (IDP) enables differentiation between clinical endotypes, with linked stratified medical therapy leading to a reduced symptom burden and a better quality of life. Interventionists are therefore well placed to make a positive impact with more personalised care. Despite adjunctive tests of coronary function being supported by contemporary guidelines, IDP use in daily practice remains limited. More widespread adoption should be encouraged. This article reviews a stratified approach to INOCA, describes a streamlined approach to the IDP and highlights some practical and safety considerations.
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Ang et al. (2021) conducted a review in Ischaemia with non-obstructed coronary artery disease (INOCA). Interventional diagnostic procedure (IDP) was evaluated. The interventional diagnostic procedure enables differentiation between INOCA clinical endotypes, allowing for stratified medical therapy to reduce symptom burden and improve quality of life.
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