Key result
Transcatheter aortic valve implantation decreased mean QT dispersion from 82.8 at baseline to 65.8 at 1 week.
Why the study?
Does transcatheter aortic valve implantation (TAVI) improve QT dispersion in patients with severe aortic stenosis?
Observational (n=100)
Does transcatheter aortic valve implantation (TAVI) improve QT dispersion in patients with severe aortic stenosis?
TAVI significantly reduces QT dispersion in patients with severe aortic stenosis, which may indicate a reduction in the risk of ventricular arrhythmias.
Answers are grounded in this paper and cite their sources.
TAVI-associated QT dispersion reduction may signal lower arrhythmia risk in severe AS; hypothesis-generating and requires randomized confirmation before practice change.
BACKGROUND/AIM: Electrophysiological changes are observed following mechanical stretches due to pressure overload in patients with severe aortic stenosis (AS). The electrical instability occurs after depolarization and dispersion of repolarization. The aim of this study was to evaluate changes in ventricular repolarization following transcatheter aortic valve implantation (TAVI). MATERIALS AND METHODS: Thestudypopulationincluded 100 consecutive patients with severe AS thatunderwent TAVI. Electrocardiography (ECG) was performed at baseline, immediately after TAVI, and 1 week after TAVI. RESULTS: The mean age of the patients was 78.2 ± 7.2 years. Thirty-four (34%) of the patients were male and 66 (66%) were female. Compared to the baseline, mean QT dispersion (QTd) immediately after TAVI and 1 week after TAVI decreased significantly (82.8 ± 26.5,75.6 ± 25.2, and 65.8 ± 28.3, respectively, P < 0.001). Likewise, compared to the baseline, mean corrected QTd (QTcd) immediately after TAVI and 1 week after TAVI decreased significantly (84.7 ± 25.2, 76.7 ± 30.8, and 69.1 ± 31.4, respectively, P < 0.001). CONCLUSION: QTd is indicative of heterogeneity of ventricular refractoriness and is prolonged in patients with AS. Following TAVI, a decrease in QTd might reduce the risk of ventricular arrhythmia in patients with severe AS.
No takes yet. Share an insight, caveat, or question.
Kasapkara et al. (2015) conducted an observational in Severe aortic stenosis (n=100). Transcatheter aortic valve implantation (TAVI) vs. Baseline (pre-TAVI) was evaluated on QT dispersion (QTd) at 1 week (p=<0.001). Transcatheter aortic valve implantation decreased mean QT dispersion from 82.8 at baseline to 65.8 at 1 week.
Synapse has enriched 10 related papers. Consider them for comparative context: