Key result
Enterovirus D68 was confirmed in 32 cases among screened respiratory samples, with overall enterovirus detected in 7.4% of samples.
Observational
No
EV-D68 was circulating in the northwest of England in late 2014, causing mild to severe respiratory infections, particularly in patients with predisposing comorbidities.
Supports clinician awareness for EV-D68 in comorbid respiratory patients; leaves open current prevalence and longitudinal impact.
Aim: A prospective study was undertaken to establish the prevalence of enterovirus D68 (EV-D68) in the northwest of England. Patients & samples: In the period 24 October through 31 December 2014, respiratory samples were screened by a specific real-time PCR and EV-D68 was identified by nucleotide sequence-based typing. Results: Enterovirus was detected in 7.4% of samples and EV-D68 was confirmed in 32 cases. Phylogenetic analysis showed that EV-D68 strains corresponded to clades A and B. Clinical presentation of cases ranged from mild to severe respiratory infection. The majority of cases had comorbidities that might predispose to severe infection. Conclusion: EV-D68 was circulating in our region during late 2014 and has the potential to cause severe disease.
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Machin et al. (2016) conducted an observational in Respiratory infection. Enterovirus D68 was evaluated on Prevalence of enterovirus D68. Enterovirus D68 was confirmed in 32 cases among screened respiratory samples, with overall enterovirus detected in 7.4% of samples.
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