Key result
Collagen from fascia specimens of patients with adolescent idiopathic scoliosis aggregated platelets less readily and was associated with a prolonged bleeding time compared to non-scoliotic controls.
Why the study?
Is collagen-induced platelet aggregation and bleeding time abnormal in patients with adolescent idiopathic scoliosis compared to non-scoliotic controls?
Case-Control
Is collagen-induced platelet aggregation and bleeding time abnormal in patients with adolescent idiopathic scoliosis compared to non-scoliotic controls?
Collagen abnormalities in adolescent idiopathic scoliosis lead to reduced platelet aggregation and prolonged bleeding time, persisting after growth cessation.
Answers are grounded in this paper and cite their sources.
Should not yet change perioperative management in adolescent idiopathic scoliosis; leaves open collagen defects' role in pathogenesis or bleeding risk.
Collagen is the main supportive protein of connective tissue. Another of its functions is the initiation of haemostasis by activation of the platelets. It has been suggested that collagen is abnormal in idiopathic scoliosis. The present study lends further support to this view: collagen of fascia specimens from patients with adolescent idiopathic scoliosis was found to aggregate platelets less readily than collagen from non-scoliotic controls and suspensions of fascia patients with adolescent idiopathic scoliosis contained more collagen than those from the controls. The collagen abnormality is probably also reflected in a prolonged bleeding time. The changes in the collagen in patients with scoliosis persist at least for some years after the cessation of growth.
No takes yet. Share an insight, caveat, or question.
Udén et al. (1980) conducted a case-control in Adolescent Idiopathic Scoliosis. Adolescent idiopathic scoliosis vs. Non-scoliotic controls was evaluated on Platelet aggregation and bleeding time. Collagen from fascia specimens of patients with adolescent idiopathic scoliosis aggregated platelets less readily and was associated with a prolonged bleeding time compared to non-scoliotic controls.
Synapse has enriched 10 related papers. Consider them for comparative context: