Key result
Idiopathic scoliosis patients showed no statistically significant differences in bleeding time, platelet aggregation, or platelet morphology compared to normal controls.
Why the study?
Are there functional abnormalities and ultrastructural changes in platelets of patients with idiopathic scoliosis compared to normal individuals?
Population
52 idiopathic scoliosis patients aged 7 to 28 years and 49 normal individuals aged 8 to 38 years as a…
Design
Case-control
Authors
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Supports intact platelet function in idiopathic scoliosis; hypothesis-generating for contractile protein role in pathogenesis.
Case-Control (n=101)
Are there functional abnormalities and ultrastructural changes in platelets of patients with idiopathic scoliosis compared to normal individuals?
Idiopathic scoliosis patients have normal platelet function and morphology, suggesting contractile proteins do not play a major role in the pathogenesis of the disease.
Suk et al. (1991) conducted a case-control in Idiopathic scoliosis (n=101). Idiopathic scoliosis vs. Normal individuals was evaluated on Bleeding time, platelet aggregation test, titers of platelet plasminogen activator inhibitors, and electron microscopic findings. Idiopathic scoliosis patients showed no statistically significant differences in bleeding time, platelet aggregation, or platelet morphology compared to normal controls.
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