Platelets from patients with idiopathic scoliosis exhibit a higher negative surface charge, which may explain previously observed functional and structural abnormalities.
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Higher negative platelet charge may underlie IS abnormalities; case-control data leave this hypothesis-generating pending prospective studies.
In order to assess the negative surface charge on platelets from patients with idiopathic scoliosis (IS) and suitable controls, formalin-fixed cells were examined by the two-phase aqueous polymer separation system and by binding of cationised ferritin. The results show that IS platelets have a higher negative surface charge. This could be responsible for several functional and structural abnormalities observed previously in IS platelets.
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Yarom et al. (2009) studied this question.
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