Key result
Captopril enhanced in vitro production of ANG I but blocked the production of [Val5]-ANG II and [Val5]-ANG-(2-8) in central venous blood from sodium-deficient sheep.
In vitro captopril enhances ANG I production while blocking ANG II and ANG III production in sheep blood, suggesting blood production forms a small part of total body production.
Answers are grounded in this paper and cite their sources.
Cautions against clinical extrapolation from ovine in vitro data; leaves open the relative contribution of circulating angiotensin production.
The effect of captopril on in vitro production of angiotensin I (ANG I), [Val5]-angiotensin II ([Val5]-ANG II) and [Val4]-angiotensin III ([Val5]-ANG-(2-8)) in central venous blood taken from sodium-deficient sheep was studied. 2. Captopril enhances in vitro production of ANG I but blocks the in vitro production of [Val5]-ANG II and [Val5]-ANG-(2-8). 3. The production of ANG I in blood is faster than that of [Val5]-ANG II and [Val5]-ANG-(2-8). 4. The half-life of [Val5]-ANG II and [Val5]-ANG-(2-8) in vitro in blood in the presence of captopril was 10 and 14 min, respectively. 5. This in vitro study suggests that the production of [Val5]-ANG II and [Val5]-ANG-(2-8) in blood forms a small part of the total body production of each peptide.
No takes yet. Share an insight, caveat, or question.
Fei et al. (1981) studied Sodium-deficient sheep. Captopril was evaluated on In vitro production of angiotensin I, II, and III. Captopril enhanced in vitro production of ANG I but blocked the production of [Val5]-ANG II and [Val5]-ANG-(2-8) in central venous blood from sodium-deficient sheep.
Synapse has enriched 10 related papers. Consider them for comparative context: