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Humoral and cellular defense mechanisms in the mammary gland play an important role in protection against infection. Opsonization of invading microorganisms is considered the most important function of immunoglobulins in mammary secretions. Bacteria also can be opsonized by complement and antibody or by direct attachment of complement activated through the alternate pathway. Opsonized microorganisms with immunoglobulin G and complement possess a high affinity to phagocyte Fc or complement (C3b) receptors, respectively. receptors promote phagocytosis whereas complement C3b receptors are responsible for attachment of bacteria to phagocytes.
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S. P. Targowski (1983) studied this question.
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