Answers are grounded in this paper and cite their sources.
Experimental study demonstrates targeted antibody internalization in cancer cells via a folate-conjugated crosslinker, highlighting a novel strategy for intracellular antibody delivery.
We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This crosslinker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.
No takes yet. Share an insight, caveat, or question.
Funamoto et al. (2015) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: