Key result
Peripheral venous pressure at peak exercise inversely correlated with peak oxygen uptake (R = -0.66, p < 0.01) in patients with Fontan circulation.
Why the study?
In Fontan circulation, central venous pressure rises during exercise to increase preload, but whether peak exercise peripheral venous pressure inversely correlates with exercise capacity remained to be tested.
Observational (n=17)
No
Effect estimate: R = -0.66
p-value: p=<0.01
Exercise-induced peripheral venous hypertension correlates with exercise intolerance in patients with Fontan circulation, suggesting peak oxygen uptake is a useful index for evaluating congestion.
Exercise-induced peripheral venous hypertension may signal limited capacity in Fontan patients; hypothesis-generating for noninvasive monitoring pending larger validation.
Owing to the absence of a sub-pulmonary ventricle, the central venous pressure rises in patients with Fontan circulation. During exercise, central venous pressure may rise further to increase the systemic ventricular preload and cardiac output. We performed a single-centre prospective trial of cardiopulmonary exercise test while monitoring peripheral venous pressure which strongly correlates with central venous pressure. The objective of this study was to test the hypothesis that peripheral venous pressure at peak exercise inversely correlates with exercise capacity in patients with Fontan circulation. Seventeen patients following Fontan operation performed cardiopulmonary exercise test while monitoring peripheral venous pressure. Peak oxygen uptake, heart rate reserve, peak oxygen pulse (divided by body surface area), and peripheral venous pressure at peak exercise were measured. Correlations of peripheral venous pressure at peak exercise with the peak oxygen uptake, heart rate reserve, and peak oxygen pulse were evaluated. The peripheral venous pressure at peak exercise inversely correlated with the peak oxygen uptake (R = -0.66, p < 0.01), heart rate reserve (R = -0.6, p < 0.05), and peak oxygen pulse (R = -0.48, p < 0.05). Exercise-induced peripheral venous hypertension correlates with exercise intolerance in patients with Fontan circulation. Peak oxygen uptake is a useful index for evaluating the status of congestion in the daily life of patients with Fontan circulation.
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Ono et al. (2021) conducted an observational in Fontan circulation (n=17). Peripheral venous pressure at peak exercise was evaluated on Peak oxygen uptake (R = -0.66, p=<0.01). Peripheral venous pressure at peak exercise inversely correlated with peak oxygen uptake (R = -0.66, p < 0.01) in patients with Fontan circulation.
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