Key result
Female gender was associated with significantly higher in-hospital major adverse cardiac events compared to men among patients with STEMI undergoing primary PCI, after adjusting for comorbidities.
Why the study?
The study was conducted to assess how gender disparities impact in-hospital, short-term, and long-term major adverse cardiovascular events among STEMI patients undergoing primary PCI.
Does female gender impact major adverse cardiovascular events in patients with STEMI undergoing primary PCI compared to male gender?
Meta-Analysis
Does female gender impact major adverse cardiovascular events in patients with STEMI undergoing primary PCI compared to male gender?
Women with STEMI undergoing primary PCI experience higher in-hospital MACE than men even after adjusting for comorbidities, emphasizing the need for targeted risk reduction.
Women with STEMI undergoing primary PCI show higher adjusted in-hospital MACE risk; supports focused periprocedural care while confirming comorbidity adjustment largely equalizes short- and long-term outcomes.
INTRODUCTION: To assess how gender disparities impact major adverse cardiovascular events during hospitalization, as well as in the short and long term, among patients with ST-elevation myocardial infarction who undergo primary PCI. EVIDENCE ACQUISITION: PubMed, Scopus and Cochrane database were searched for relevant studies. Studies were included if all comers with STEMI, reported gender specific patient characteristics, treatments and outcomes. Odds ratio and 95% confidence interval were calculated using random effect model. EVIDENCE SYNTHESIS: =0.00). CONCLUSIONS: The findings of this comprehensive meta-analysis indicate higher major adverse cardiac events among women with STEMI who underwent PPCI. After adjusting for comorbidities, the difference between women and men showed insignificant at short term and long term but remained significant at in-hospital. Female patients exhibited a higher prevalence of cardiovascular risk factors than men. Implementing intensive cardiovascular risk reduction strategies in women may offer a pathway to address this gender disparity.
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Patel et al. (2025) conducted a meta-analysis in ST-elevation myocardial infarction. Female gender vs. Male gender was evaluated on Major adverse cardiovascular events. Female gender was associated with significantly higher in-hospital major adverse cardiac events compared to men among patients with STEMI undergoing primary PCI, after adjusting for comorbidities.
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