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September 1, 1981Anesthesia & Analgesia

Isoflurane

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Key result

Isoflurane is a chemically stable, potent inhalation anesthetic with low toxicity and favorable muscle relaxation, though it may cause respiratory depression and reduced blood pressure.

Design

Review

Authors

JWJ. G. WadeSt. Vincent's University HospitalWSWendell C. StevensUniversity of Iowa

Discussion

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Implication

Supports isoflurane selection for stability needs; leaves open comparative trials versus newer agents.

Structured PICO

E
Exposure
Isoflurane

Isoflurane is a chemically stable, potent inhalation anesthetic with a favorable safety profile regarding hepatic, renal, and arrhythmogenic toxicity, representing a significant improvement over earlier agents.

Limitations

  • The frequency and/or significance of tachycardia and dilation of muscle blood vessels in clinical practice remain to be established.

Cite This Study

Wade et al. (1981) reported a review. Isoflurane was evaluated. Isoflurane is a chemically stable, potent inhalation anesthetic with low toxicity and favorable muscle relaxation, though it may cause respiratory depression and reduced blood pressure.

synapsesocial.com/papers/6a95762caa92d0f3572ca455https://doi.org/10.1213/00000539-198109000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advantages and Guidelines for Using Isoflurane1992 · 27 citations
  2. 2Sevoflurane1975 · 332 citations
  3. 3Desflurane - Revisited2012 · 24 citations
  4. 4Cardiovascular Effects of Sevoflurane Compared with Those of Isoflurane in Volunteers1995 · 229 citations
  5. 5Effects of Desflurane and Isoflurane on Arterial Oxygenation and Hemodynamics during One-lung Ventilation2003