Key result
The overall seroprevalence of murine norovirus infection in Korean laboratory animal facilities was 15.0%, with genetically modified mice showing the highest prevalence at 27.0%.
Cross-Sectional (n=745)
Yes
Alerts lab facilities to elevated MNV risk in GM mice; leaves open effects on research reproducibility and need for standardized controls.
Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from 15 animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals showed that they were homologous (100%) with MNV-4.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2010) conducted a cross-sectional in Murine Norovirus (MNV) infection (n=745). Laboratory animal facility housing was evaluated on Seroprevalence of MNV infection by ELISA. The overall seroprevalence of murine norovirus infection in Korean laboratory animal facilities was 15.0%, with genetically modified mice showing the highest prevalence at 27.0%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: