Key result
RNAi knockdown of the deubiquitylating enzymes TbUsp7 and TbVdu1 in Trypanosoma brucei reduced the abundance of invariant surface glycoproteins ISG65 and ISG75 and perturbed endocytosis.
Multiple ubiquitylation pathways, including TbUsp7 and TbVdu1, control surface proteome expression and trafficking in African trypanosomes.
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AP-1-independent ISG75 trafficking refines suramin uptake models; leaves open DUB contributions to T. brucei drug sensitivity.
Zoltner et al. (2015) studied Trypanosoma brucei infection. RNAi knockdown of TbUsp7 and TbVdu1 vs. Uninduced cells was evaluated on Protein abundance of invariant surface glycoproteins (ISG65 and ISG75). RNAi knockdown of the deubiquitylating enzymes TbUsp7 and TbVdu1 in Trypanosoma brucei reduced the abundance of invariant surface glycoproteins ISG65 and ISG75 and perturbed endocytosis.
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