Despite causing severe repression of host cell biosynthesis, herpes simplex virus Type 2 infection induces the transcription and accumulation of specific cellular genes.
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Indicates selective transcriptional activation by HSV-2 despite host repression; leaves open relevance to human infection.
Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.
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Kemp et al. (1986) studied this question.
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