Key result
Diabetic patients with gastrointestinal symptoms exhibited altered brain-gut axis interoception, evidenced by decreased heart rate variability, prolonged evoked potential latencies, and a shift in insular brain source localization.
Case-Control (n=30)
Single-blind
Yes
Absolute Event Rate: 90% vs 125%
p-value: p=0.008
Diabetic autonomic neuropathy is associated with peripheral nervous degeneration and changes in brain dipole sources that correlate with gastrointestinal symptoms and heart rate variability.
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Altered interoception may underlie GI symptoms in diabetic autonomic neuropathy; hypothesis-generating and should not yet change practice.
Brock et al. (2013) conducted a case-control in Diabetic Autonomic Neuropathy with severe gastrointestinal symptoms (n=30). Diabetes with autonomic neuropathy vs. Healthy volunteers was evaluated on Heart rate variability (SDANN) (p=0.008). Diabetic patients with gastrointestinal symptoms exhibited altered brain-gut axis interoception, evidenced by decreased heart rate variability, prolonged evoked potential latencies, and a shift in insular brain source localization.
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